Translational Research

Superiority of the Alg-RGD-E hydrogels to maintain/encapsulate the seeded cells and provide a more favorable microenvironment for cell growth due to the more efficient crosslinking process to form a hydrogel.

Method to eradicate mosquitoes based on engineering the male mosquito’s microbiome. One of the common bacteria strains in the present in the microbiome is being genetically engineered to express the well-known and approved to use, Bacillus thuringiensis israeliensis (Bti) toxin. The toxin is vertical inheritance and being delivered to egg-laying locations. When the larvae hatch, it die and the toxin is spread to the water reservoir.

Improve system to incorporate unnatural amino acids (UAAs) Alkynes or Azobenzenes to protein using improved tRNA synthetases. This introduces new chemical and physical properties, such as binding lipid to improve protein/peptide stability in serum, introduce photo-temperature switch that can influence protein-protein/peptide drug interaction.

Method to improve protein yield, by incorporation of unnatural amino acids (UAAs) into proteins expressed in E. coli, that lead to lower kinetics and in the same time increase in protein yield. Another method is to improve and synchronize expression of two proteins using unique elements named ribosome termination structures (RTS).

An easy, straightforward, environmentally friendly methodology to synthesis 3.5-5 nm antimicrobial carbon dots (C-dots) that are biocompatible and selective towards Pseudomonas aeruginosa. Possible applications such as coating of medical device and surfaces, selective labeling for diagnostic, water purification and more.