Therapeutics & Treatments

Based on ML-tool for drug discovery and repurposing, Eravacycline was identified to anti-cancer activity and more specifically pancreatic cancer

The presented invention offers inhibiting of purine nucleobase transporter SLC (SLC43A3) as novel way for treating various cancers.

A novel platform for transplantation devices, designed to promote an immunoregulatory microenvironment suitable for cell transplantation and autoimmune regulation. The scaffold is based on macroporous alginate with the ability to bound growth factors.

Dual activity, anti- Quorum Sensing and anti- inflammatory, compounds for bacterial infection. The synthesized compounds are derivatives from Pepper and Curcumin. Around 60 compounds were synthesized and characterized for their toxicity, Quorum sensing inhibition, anti-bacterial activity and NF-kB inhibition. Few promising compounds were generated.

Novel targeted prodrugs that address drug localization issue in orally administration by using phospholipase A2 (PLA2) for treatment of inflammatory bowel disease. PLA2 expression/activity is significantly elevated in the inflamed intestinal tissues of the patients.

A technology based on positively charged polysaccharides for RNA transfection, including miRNA. Quaternized (Q)-starch/miR-197 complexes for topical treatment of Psoriasis were developed. Enhancement of skin permeability of the complex was achieved by pre-treatment with low frequency ultrasound.

Novel anti-Superoxide Dismutase 1 (SOD1) peptide and antibody that prevent SOD1 aggregation, as potential therapeutic agents for Amyotrophic Lateral Sclerosis (ALS).

New method named ‘Fragment based virtual screening’ (FBVS) to discover small molecules that binds desire target macromolecules, using the combination of NMR-fragment based screening and machine learning-based computational optimization to enhance binding and inhibition of the target.

Novel copper-polysachharide (PS-Cu) complex demonstrating dual antifungal and antibacterial activity. In addition anti-biofilm activity was shown. The complexe is highly stable both in temperature and pH.

in vitro technology for maturation of spermatogonium. The system is comprised from culturing of spermatogonium (undifferentiated male germ cells) in a 3D methylcellulose culture system (MCS) with specific designed culture medium that contains an optimized medium for differentiation and maturation the spermatogonium into mature sperm cell.

DOPAM is a new family of chemical entities that combines mannitol and L-DOPA. While introducing DOPAM to the blood circulation, it releases both LDOPA and mannitol over a period of 24 hours.

A combination therapy of FDA-approved N-Methyl D- Aspartate receptor (NMD-A) receptor blocker and a Transforming Growth Factor beta (TGF-β) receptor antagonist, for treatment of brain diseases associated with blood-brain barrier (BBB) dysfunction, such as epilepsy, traumatic brain injury, stroke, and neurodegenerative diseases.

‘Succilators’ are various recombinant polypeptides that binds succinate and reduce its level. This new mode of action can be relevant for a succinate-associated disease or condition, such as inflammatory bowel disease (IBD), urolithiasis, rheumatoid arthritis, cardiac hypertrophy, inflammation, kidney stones and hypertension.

hAAT derivatives generated using site-directed mutagenesis or directed evolution approaches to generate hAAT with superior anti-inflammatory activity. The mutants were expressed and purified from cell-lines.

Novel non-invasive topical administration of high-molecular weight hyaluronic acid (HMW HA, up to 8000kDa). Two key components enable the skin penetration of HA, pre-treatment of the skin with short duration ultrasound and complexing HA with quaternary starch (Q-starch).

A novel phosphate binder (PhB), based on biocompatible silica nanoparticles (NP) decorated with tethered phosphate-binding peptides (NP-pep). The NP-pep can serve as therapeutic agent for hyperphosphatemia as well as anti-tumorigenesis.

A novel anionic polyplex nanoparticle delivery system of nucleic acid into cells as a method of treating various diseases and disorders. This was used to targert hepatocytes and cardiac macrophages at post-myocardial infraction.

New kinase inhibitory peptides for the upstream region of the kinase’s coding sequence, PKCeta, that can serve as novel anti-cancer therapeutic.

A non-invasive methodology based on low-intensity ultrasound to treat disease and disorder associated with hyperproliferating cells, such as cancer, without damaging healthy cells around.