Drug Delivery Platforms

Novel polymeric system and production process for self-assembled drug-loaded NPs. In addition to increase treatment efficacy of the NPs compared to unencapsulated drugs, the current invention also can offer ease and reproducibility of preparation, ease of storage and administration in a sterile form, satisfying drug-loading capacity, low toxicity, and feasibility for scale-up production

A technology based on positively charged polysaccharides for RNA transfection, including miRNA. Quaternized (Q)-starch/miR-197 complexes for topical treatment of Psoriasis were developed. Enhancement of skin permeability of the complex was achieved by pre-treatment with low frequency ultrasound.

Peptide-polypeptide co-assembled nanoparticles for intracellular drug delivery of active ingredients. The NPs have the capacity to deliver amphiphilic drugs. By coating the co-assembled NPs with cationic β-sheet peptide (PFK), the NPs were targeted to the mitochondria.

A novel anionic polyplex nanoparticle delivery system of nucleic acid into cells as a method of treating various diseases and disorders. This was used to targert hepatocytes and cardiac macrophages at post-myocardial infraction.